If your NHL diagnosis is linked to EtO exposure, then you may qualify for a claim and might be entitled to fair compensation. Similarly, family members who are mourning the loss of a loved one due to an EtO-related cancer may also be eligible to file a claim and receive compensation.
Studies linking EtO exposure to NHL
A comprehensive paper published in 2023 has found that exposure to pesticides, including EtO, may increase the risks of developing non-Hodgkin’s lymphoma.
In another study, high exposure to EtO has been seen to elevate the likelihood of developing lymphoma by more than four times.
Residents near EtO-emitting facilities have the highest chances of exposure, which may lead to the development of NHL. Listed below are the most common signs and symptoms of NHL:
- Swelling of lymph nodes
- Pain in the abdomen or bloating
- Chest pain or trouble breathing
- Fever and night sweats
- Weight loss
The biological mechanism linking EtO to NHL
Ethylene oxide operates as a direct-acting DNA alkylating agent, meaning it reacts chemically with DNA without needing metabolic activation. This creates DNA adducts and mutations in cells exposed to EtO.
When a person inhales ethylene oxide, the gas is absorbed through the lungs and distributed systemically throughout the body. This systemic distribution means that lymphoid tissues, including lymph nodes and circulating lymphocytes, become exposed to EtO and subject to its DNA-damaging effects. The chemical bonds that EtO forms with DNA bases interfere with normal cellular processes and create genetic instability.
EtO exposure produces dose-related increases in DNA and protein adducts and induces several types of genetic damage:
- DNA adducts that interfere with normal replication
- Chromosomal abnormalities that disrupt gene organization
- Mutations that alter the genetic code in lymphoid cells
Persistent DNA damage in vulnerable lymphoid precursor cells can trigger the transformation into cancer cells that defines lymphomas like NHL. Once lymphocytes collect enough mutations in their growth-control genes, they start multiplying without limits, creating the cancerous masses that characterize non-Hodgkin's lymphoma.
Key facts
EPA carcinogen classification
2016
EtO emitting facilities
100+ nationwide
Risk radius
Up to several miles