Prostate cancer and AFFF: PSA levels matter in tracking firefighter health

Treven Pyles

By Treven Pyles

Posted on September 22nd, 2025

Researchers have found that firefighters are more likely to develop prostate cancer than the general population by 21%-28%. Since the 1960s, firefighters have been exposed to harmful chemicals, especially those found in Aqueous Film-Forming Foam (AFFF), which is widely used in firefighting.

PFAS (perfluoroalkyl substances) are persistent chemicals that stay in the environment or the body for long periods of time and cannot naturally decompose. Over time, these substances accumulate in the body, creating long-term health risks that may not manifest for years after exposure.

The PFAS-Prostate Cancer Connection

Research demonstrates concerning links between PFAS exposure and prostate health complications. Laboratory studies reveal that PFAS exposure can alter prostate cell metabolism and stem cell behavior, providing clear biological mechanisms that contribute to cancer development. There is evidence that firefighters exposed to PFAS have altered DNA methylation at prostate cancer-related genes, indicating direct occupational influences on prostate biology.

Firefighters are exposed to various hazardous sources, such as smoke, diesel exhaust, and AFFF. As a result of this toxic combination, firefighters are significantly more likely to develop prostate cancer than the general population. Since PFAS compounds persist in the body for years or decades, cellular changes may lead to cancer years or decades after exposure.

Why PSA Monitoring is Critical for Firefighters

PSA (Prostate-Specific Antigen) testing serves as an important early detection tool for prostate cancer. Prostate tissue produces a protein that can be measured in the blood, and elevated readings may indicate prostate cancer, benign prostatic hyperplasia, or prostatitis. PSA monitoring is particularly important for firefighters, whose risk profile is elevated.

For firefighters at risk, the International Association of Fire Fighters (IAFF) and other fire service health organizations have developed specific recommendations:

  • Begin PSA screening at age 40-45 for firefighters with AFFF exposure
  • Establish baseline PSA levels in early adulthood to effectively track changes over time
  • Conduct annual testing for higher-risk individuals
  • Maintain detailed exposure documentation for medical and legal purposes

Regular PSA screening leads to significantly better outcomes for firefighters than those who do not. Testing more frequently leads to earlier cancer detection, usually with lower PSA levels at diagnosis and better prognosis due to a lower Gleason score and localized tumors. Early detection dramatically increases the chances of survival, as opposed to advanced prostate cancer.

Secure the Compensation You Deserve with ELG Law

If you're a firefighter who has been exposed to AFFF and developed prostate cancer, you may be eligible for significant compensation. Civilian and military firefighters can seek compensation through two primary legal channels with the help of ELG Law. Our firm handles liability claims against manufacturers for firefighters who used AFFF during the course of their careers, as well as VA disability claims for military firefighters who were exposed to AFFF.

With over 35 years of experience in toxic exposure cases, our streamlined process only requires your medical records and employment or military service records. It is essential to provide evidence of AFFF exposure, such as training logs, incident reports, and service records.

We provide free case evaluations and pursue maximum compensation for medical expenses, lost wages, and other damages. Health and financial security should not be compromised by AFFF exposure. Contact ELG Law today to find out how we can help you get the compensation you deserve.